Sample Originator: C. S. J. Cazin, R. B. Bedford, Michael B. Hursthouse, Thomas Gelbrich, Peter N. Horton, Mark E. Light and Simon J. Coles.



Identification Number:10.5258/ecrystals/41
Controlled Keywords:high-activity catalysts, Suzuki Coupling, amination reactions, deactivated aryl chloride substrates
Date Created:09 May 2002
Deposited On:21 Jan 2008 15:28
Deposited By:A.N. Admin

Depositor Comments

A range of ortho-metalated catalysts with alkylphosphine ligands of the general formula [Pd(X)(2N,C-C6H4CH2NMe2)(PR3)] have been synthesized, and the crystal structures of five examples (R = Cy, X = TFA, OTf, Cl, I; PR3 = PCy2(o-biphenyl), X = TFA) have been determined. The crystal structures of two dimeric precursor complexes, [{Pd(-TFA)(2N,C-C6H4CH2NMe2)}2] and [{Pd(TFA)(2N,C-C6H4CH=NiPr)}2], have also been determined. The application of the phosphine adducts to both Suzuki coupling and Buchwald-Hartwig amination reactions with aryl chloride substrates was examined, and the performance of these catalysts versus conventional palladium sources was evaluated. In general the palladacyclic complexes show considerably enhanced activity. Typically, the best activity is seen with tricyclohexylphosphine adducts in Suzuki coupling and tri-tert-butylphosphine analogues in amination reactions. In nearly all the amination reactions performed, small amounts of a second product species were observed, namely 4,6-bis(aryl)-3,4-dihydro-2H-[1,4]oxazines. The crystal structure of one example, 4,6-bis(4-methoxyphenyl)-3,4-dihydro-2H-[1,4]oxazine, was determined. Studies on the activation of palladacyclic precatalysts in the coupling of morpholine led to the isolation of a morpholine adduct, [Pd(TFA)(2N,C-C6H5CH2NMe2){NH(CH2CH2)O}], which was structurally characterized by X-ray analysis.DOI: 10.1021/om020841+

Data collection parameters

Chemical formulaC15 H20 F3 N2 O3 Pd
Crystal morphology
Crystal systemMonoclinic
Space group symbolP2(1)/c
Cell length a9.3727(9)
Cell length b19.1440(15)
Cell length c20.2492(19)
Cell angle alpha90.00
Cell angle beta101.41
Cell angle gamma90.00
Data collection temperature120(2)

Refinement results

Solution figure of merit
R Factor (Obs)0.0535
R Factor (All)0.0682
Weighted R Factor (Obs)0.1097
Weighted R Factor (All)0.1147

Citation: Cazin, C. S. J. and Bedford, R. B. and Hursthouse, Michael B. and Gelbrich, Thomas and Horton, Peter N. and Light, Mark E. and Coles, Simon J. (2002) University of Southampton, Crystal Structure Report Archive. (doi:10.5258/ecrystals/41)
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